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This approval is a significant decision because people living with excess weight or obesity and established cardiovascular disease and without diabetes have never had an FDA-approved treatment option that lowers weight and reduces the likelihood of another cardiovascular event, said A Michael Lincoff (Cleveland Clinic, Cleveland, USA) and the lead study author of the SELECT outcomes trial
By activating GLP-1 receptors, semaglutide stimulates insulin secretion, reduces the production of glucagon (a hormone that raises blood sugar levels), slows down stomach emptying, and promotes feelings of fullness [2]
The practical recommendation: keep RTD formats for injection days and early mornings when nausea is at its worst
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