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At therapeutic doses, GLP-1 drugs cross the blood-brain barrier and dampen dopamine signaling in the brains core reward center, making addictive substances less rewarding

GLP-1RA as an independent class of drug is also noteworthy in reduction of weight in patients with and without poor glycaemic control with multiple trials backing the efficacy of agents including semaglutide and liraglutide (116)

Brain enzyme activities after intracerebroventricular parenteral-route administration [PMID: 8666027] Laboratory literature summary: Brain enzyme activities after intracerebroventricular parenteral-route administration of streptozotocin in rats receiving acetyl-L-carnitine

ICSI, intracytoplasmic sperm injection