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The most representative examples of small molecular antioxidants involve vitamins C, E, and A, polyphenols of which about half are flavonoids, carotenoids, glutathione, curcumin, melatonin, and others (Niki 2016)

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Avoid strongly alkaline conditions above pH 8 that promote amide hydrolysis, and avoid strongly oxidising conditions that could modify the Trp9 residue despite the Nle4 substitution eliminating the oxidation-sensitive methionine of native -MSH