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Morning injection followed by twice daily topical application provides continuous peptide exposure
Patients with established type 2 diabetes on sulfonylureas or insulin need glucose monitoring intensified to every 4 weeks during the first 12 weeks of the 8 to 12 mg range because the GLP-1R and GIPR components can substantially lower postprandial glucose and provoke hypoglycemia when combined with secretagogues [7, 13]
In sermorelin trials for GH deficiency, measurable IGF-1 increases were typically seen within 4 to 8 weeks of nightly dosing
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