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As we've discussed, GLP-1 helps regulate appetite, slow gastric emptying, and improve blood sugar control
Rotate injection sites each week to prevent localized reactions
Less body weight means less compressive load on the knee with every step Adipose tissue produces inflammatory signalling molecules (IL-6 and TNF-alpha) that drive joint pain, and reducing fat tissue reduces those signals 3 The IDEA trial in 2013 demonstrated clinically meaningful reductions in pain through diet and exercise alone, without any GLP-1 medication 3 Whether semaglutide also has anti-inflammatory effects independent of weight loss, through GLP-1 receptors on immune cells, is a separate question
Moreover, there is a potential reduction in the expression of enzymes responsible for the urea cycle, a possible re-establishment of nitrogen equilibrium, and a hypothetical modification or enhancement of nitrogen levels in different tissues
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