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Your healthcare provider may ultimately adjust your titration schedule based on your response
When mechanical stress overwhelms the muscular resistance, the sarcomere units, which are assembled from myofibrils and connective fibrils and fixed by structural proteins such as actin, dystrophin and titin, become overstretched and disrupted, resulting in membrane failure and leakage of the sarcoplasmic components
Nat Rev Urol (2013) 10(4):21926
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