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Serotonin syndrome: Combining MDMA with MAO inhibitors, SSRIs, lithium, or other serotonergic agents precipitates serotonin syndrome, a potentially fatal triad of hyperthermia, neuromuscular abnormalities, and altered mental status requiring emergency intervention
Triterpenoids CDDO and CDDO-Me down-regulate FLIP expression and sensitize AML cells to TRAIL-induced apoptosis
The preclinical evidence: what the studies actually show Honest assessment of the evidence requires separating what has been demonstrated from what has been assumed
Here, we provide the first evidence of improved healthspan and age-related survival with a therapeutic mAb by demonstrating that treatment with an IGF-1R antagonist in older mice significantly and preferentially improves several indices of healthspan, reduced death from neoplastic disease, and increased mean and median lifespan in females
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