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DHODH is a flavin-dependent protein, present in the inner mitochondrial membrane, that converts DHO to orotate, reducing ubiquitin to pantothenol and producing lipophilic antioxidants, which inhibits LPO accumulation and ferroptosis (46)
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It has been established that the speed of replication fork progression is regulated by TIPIN/TIMELESS complex with oligomer form of peroxiredoxin 2 (PRDX2), as a ROS sensor, in replisome
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