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Established risk factors for venous thromboembolism (VTE) include: Obesity (BMI 30 kg/m), which increases venous stasis and pro-inflammatory states Immobility or reduced mobility , particularly relevant in patients with severe obesity Previous history of VTE or family history of thrombophilia Active malignancy or recent surgery Hormonal therapies , including combined oral contraceptives or hormone replacement therapy Pregnancy and the postpartum period Smoking , which affects endothelial function and coagulation Risk factors for arterial thrombosis (myocardial infarction, stroke) include: Type 2 diabetes mellitus , associated with endothelial dysfunction, platelet hyperreactivity, and a prothrombotic state Hypertension , causing arterial wall damage Dyslipidaemia , promoting atherosclerotic plaque formation Established cardiovascular disease Chronic kidney disease , common in diabetes and associated with increased cardiovascular risk Patients initiating GLP-1 therapy should undergo a comprehensive cardiovascular risk assessment

Warning signs that require prompt assessment include: Persistent vomiting that prevents adequate fluid or medication intake Inability to maintain nutrition or hydration Severe abdominal pain (which could indicate pancreatitis, gallbladder disease, or other serious conditions) Vomiting of undigested food consumed many hours previously Significant unintended weight loss Worsening glycaemic control despite medication adherence It is worth noting that symptoms alone cannot definitively distinguish between expected medication effects and true gastroparesis

Results vary significantly based on individual absorption and technique quality