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40 Nevertheless, accumulating evidence indicates that CR is detrimental to skeletal metabolism, as evidenced by reductions in BMD and bone mineral content (BMC), diminished bone formation indices (e.g., bone formation rate, osteoblast number), and a concomitant increase in bone resorption
No mice died or displayed apparent signs of morbidity at any stage of recovery in this study
Tesamorelin, because it stimulates real growth hormone release, produces the metabolic effects associated with elevated GH including measurable IGF-1 increases and monitoring requirements for glucose metabolism in clinical settings
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