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Tests for MTHFR, while gaining popularity, are generally unnecessary because the association of MTHFR gene mutations with various diseases have not been established as clear-cut cause-and-effect relationship

An emerging concept is that cardiolipin migration to the outer membrane of the mitochondrion is the trigger that induces misfolding into soluble oligomers of various proteins present in the cytoplasm

Criteria such as study design, reporting of cell culture conditions, and reproducibility of findings were assessed by two reviewers independently

Gastrointestinal (GI) adverse eventsparticularly nausea, vomiting, diarrhea, and constipationare the most common side effects, generally emerging during dose escalation and resolving over time