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This could explain why tirzepatide (which stimulates the GIP pathway in addition to GLP -1) can be administered at higher doses than semaglutide (which only stimulates GLP-1), without amplifying the side effects typical of GLP-1 agonists (nausea, vomiting)
Zmitek K, Amitek J, Hristov H, Butina MR, Kersmanc P, Pogacnik T
Semaglutide is given as a once-weekly subcutaneous injection , which may be more convenient for some individuals
The short answer is that they work through different mechanisms and stacking them often produces better results than either alone
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