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At the molecular level, the mechanism has been structurally resolved by NMR spectroscopy (Nature Communications, 2025): FOXO4-DRI binds to the disordered p53 TAD2 domain and forms a transiently folded complex through both the FOXO4-derived peptide region and its cationic cell permeability element
The same mechanism that helps deliver healing factors to injured tissue could theoretically support tumor growth by enhancing blood supply to cancerous cells
TB-500 is a synthetic derivative of thymosin beta 4, an endogenous peptide present in the thymus gland
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