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Scar tissue, while structurally filling the wound, lacks the functional properties of the original tissue scar tissue in tendons is weaker and less elastic, scar tissue in skin lacks normal sensation and flexibility, and scar tissue in the gut lacks normal mucosal barrier function

However, this double-blind, randomized, placebo-controlled trial assigned 99 CFS patients to monthly infusions of placebo or IVIG (0.5, 1, or 2 g/kg) for three months

Also, it was shown that the epigenetic changes (DNA methylation patterns) to be associated with oxidative stress markers 39,40