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In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (47)
It is a more potent anticancer and anti-inflammatory agent than RES (Chiou et al., 2011) and it distributes widely among the main target organs (brain, liver, kidney, heart and lung) for what seems to be a promising (Choo et al., 2014) and safe (Riche et al., 2013) therapeutic strategy
Regulatory Status and Safety Takeaway FDA Status: IGF-1 LR3 is not approved by the FDA for human therapeutic use and is highly restricted
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