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As also shown in related structural studies, the general base Glu 256 could further support the hydride transfer step of MSA-DH catalysis (Supplementary Figure S3 illustrates the spatial interplay of cofactor and substrate in the MSA-DH active site on the basis of the NAD(P) + and the MSA funnel
Other drug interactions may occur with selective serotonin reuptake inhibitors (SSRI) antidepressants, antihypertensives, and antipsychotics
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