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10.1111/bph.13426 112 WongK
The lactam bridge between Asp5 and Lys10 side chains cyclises the heptapeptide backbone and constraining it into a compact, conformationally rigid structure that stabilises the receptor-binding pharmacophore conformation required for high-affinity MC3R and MC4R engagement
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Since these cancers require a blood supply they often exhibit small friable feeder vessels which are likely to bleed with minimal trauma and produce a superficial erosion
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