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Chronic elevation (hypercortisolism or Cushing's syndrome) leads to central obesity, insulin resistance, hypertension, muscle weakness (particularly proximal), wide purple striae, facial plethora, and increased cardiovascular risk
Buonfiglio, F., Bhm, E
These initial side effects usually peak around week 2-3, then start tapering off as your body adjusts to the medication
Each one contributes something different to the fat loss equation, and together they create a synergistic effect that no single-receptor or dual-receptor compound can match
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