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Novo Nordisk - Regulatory Approval (December 2025): FDA approved the first oral GLP-1 for weight loss-Novo Nordisk's once-daily semaglutide pill-which launched in January 2026 [3]
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It is important to note that cross-trial comparisons have significant limitations
For example, smoking has been shown to modulate the insulin-like growth factor (IGF) signaling pathway, which plays a role in cell growth and survival 98,99
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