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Research comparing MT-II with MT-1 and native -MSH has established that cyclic lactam backbone constraint shifts melanocortin receptor subtype selectivity toward MC3R and MC4R relative to linear peptide analogues and with MT-II showing substantially enhanced potency at MC3R and MC4R relative to its potency ratio at MC1R compared with the linear MT-1

6 Clinical research and future perspectives 6.1 Expansion trends in clinical indications At present, the most established clinical applications of riboflavin are in FAD responsive metabolic disorders such as RTD and MADD

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