Selection and validation of genetic predictors of GLP-1R, GIPR, and GCGR We strictly adhere to the following 5 steps to identify genetic predictors: (1) We systemically searched the expression levels of GLP-1R, GIPR, and GCGR on the Human Protein Atlas website (www.proteinatlas.org, HPA) to preliminarily select the appropriate tissues [26] (Supplementary Fig
Talasaz A, Sadeghipour P, Ortega-Paz L, Kakavand H, Aghakouchakzadeh M, Beavers C, Fanikos J, Eikelboom J, Siegal D, Monreal M, Jimenez D, Vaduganathan M, Castellucci L, Cuker A, Barnes G, Connors J, Secemsky E, Van Tassell B, De Caterina R, Kurlander J, Aminian A, Piazza G, Goldhaber S, Moores L, Middeldorp S, Kirtane A, Elkind M, Angiolillo D, Konstantinides S, Lip G, Stone G, Cushman M, Krumholz H , Mehran R, Bhatt D, Bikdeli B
They work similarly to GLP-1 agonists
This is crucial with retatrutide, as the aim is fat loss, not muscle