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By activating both receptor pathways, tirzepatide achieves reductions in HbA1c levels (typically 1.52.1% [16-23 mmol/mol] from baseline in the SURPASS clinical trials) and weight loss (averaging 5-15% of body weight in type 2 diabetes and 15-20% in obesity at the 10-15mg doses in the SURPASS and SURMOUNT trials)
Patients should work with their healthcare providers to set realistic weight loss goals and strategies
Chuaychoo B, Hunter DD, Myers AC, Kollarik M, Undem BJ
Decaffeinated options are another route if regular coffee consistently triggers nausea, and many people report no loss of enjoyment from the ritual of drinking coffee
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