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Transneuronal propagation of pathologic -synuclein from the gut to the brain models Parkinson's disease

The most commonly reported side effects in clinical trials include: Nausea Vomiting Diarrhea Constipation Most of these symptoms were mild to moderate and tended to improve over time as the body adjusted to the medication, especially when doses were increased gradually

The tissue was mechanically homogenized under ice bath conditions for making 10% homogenate that used an Automatic Sample Rapid Grinding Instrument (JingXin, Shanghai, China)