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Weight loss shot Mounjaro works by activating GLP-1 and GIP receptors, which influence appetite control, blood sugar balance, and energy regulation
By utilizing a high-fat diet-induced obese mouse model, they applied pharmacological interventions, hyperinsulinemic-euglycemic clamp studies, as well as transcriptomic and metabolomic analyses to demonstrate that this effect was associated with the activation of glucose, lipid, and branched-chain amino acid (BCAA) metabolic pathways in BAT (17)
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