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Conversely, in another phase 2b study involving patients with T2DM, tirzepatide showed significantly better efficacy in glucose control and weight loss compared to both placebo and dulaglutide, with an acceptable safety and tolerability profile (111)
Side effects are similar to those experienced with Semaglutide and Tirzepatide: nausea and gastrointestinal complaints are the most common, but only 7% of patients in a study published in The New England Journal of Medicine1 discontinued the medication due to adverse effects
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