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Genital melanosis, also known as vulvar lentiginosis and vulvar melanotic macules, is a benign lesion characterized by macular pigmentation that can involve cutaneous or mucosal sites
Abrupt cessation without planning may result in metabolic deterioration requiring intervention
Not all patients require the maximum dose
In the case of nicotine, preclinical studies showed evidence that the rewarding effects of nicotine are reduced by stimulation of GLP-1 receptors in the medial habenula, which is a brain region that mediates nicotines aversive effects [48]
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