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Proportion of treatment effect on the clinical endpoint explained by UACR for different intervention classes, from Heerspink et al, Nat Med, 2025 The investigators further showed that only 46% of the total treatment effect on kidney outcomes could be statistically explained by albuminuria change, implying that more than half of the therapeutic benefit arises from albuminuria-independent pathways
It also caused less GLP-1R internalization than GLP-1, due to the weaker -arrestin recruitment (30-50% Emax of GLP-1) 30
There are other new drugs that are closely related however, such as tirzepatide, found in Mounjaro and Zepbound
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