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Clinical studies have generally shown good tolerance at recommended doses, with most adverse effects being mild and transient

The principle of using mAbs to increase IgG catabolism was also demonstrated in NHPs, when Nixon and colleagues at Dyax Corp used phage-display selected human IgG1 mAbs with high pH-independent affinity towards FcRn to reduce circulatory IgG without affecting albumin levels in NHPs [122]

Streptozotocininduced diabetic models in mice and rats