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In a subanalysis of SURPASS-3, tirzepatide 10 and 15 mg resulted also in a relative reduction in liver fat content by 4047% compared to 11% with insulin glargine at 52 weeks [44]

The naturally occurring peptide GIP(3-30)NH 2 has been successfully used as an GIP antagonist in human studies, inhibiting the incretin effect of GIP as well as its effect on glucagon secretion [50, 51], but the therapeutic potential of GIP antagonism is still not clear

Retatrutide is a serious weight-loss drug with strong trial data, but it's only legally available in the UK through clinical trials right now

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