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it suppresses LPS-induced pro-inflammatory cytokine production in macrophages and promotes M2 polarization through MCTs and HIF-1 activation (106)
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While deletion of a single RGG motif from FUS/TLS was insufficient to eliminate co-precipitation of SMN, deletion of all three RGG motifs (producing RGG123) abolished complex assembly containing both FUS/TLS and SMN (Fig
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