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It acts as a built-in defense mechanism against the damaging effects of ultraviolet (UV) radiation
10.1111/nmo.12348 46
It typically presents as macrocytic megaloblastic anemia and neurological impairments, including sensory and motor disfunctions, predominantly in the lower extremities, ataxia, and in more advanced stages cognitive decline progressing to dementia, as well as psychiatric disturbances ( Subclinical B12 deficiency, however, is far more prevalent, affecting up to 26% of the general population
This represents a niche application distinct from the systemic effects sought with nasal or injectable administration
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