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Diese Mechanismen wurden bislang ausschliesslich in prklinischen Modellen beobachtet und bedrfen weiterer Forschung, um ihre bertragbarkeit auf humane Systeme zu besttigen
[1] The authors reported that methylquinolinium analogs with primary-amine substitutions displayed high permeability from passive and active transport across membranes, measured using two standard in-vitro models: the parallel artificial membrane permeability assay (PAMPA) and Caco-2 human intestinal cell monolayers
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