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Preclinical models have examined how this fragment influences fat cell mobilization and lipogenesis without measurable impact on insulin-like growth factor-1 (IGF-1) levels, distinguishing it mechanistically from intact growth hormone

There are also cases where patients with low B12 levels have problems with fertility or are more likely to develop dementia

Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis

(13) As a result, low levels of IF can interfere with the ability to absorb vitamin B12 and lead to a deficiency