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The lyophilized form provides inherent stability advantages over reconstituted solution, but extended exposure to temperatures above 25 degrees Celsius can initiate degradation even in powder form

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doi:10.1074/jbc.M203067200

So, when someone goes on weight-loss drugs and substantially reduces their food intake, the likelihood of deficiencies becomes even greater, unless they change their diet to include more nutrient-dense foods. Why protein matters on GLP-1s Gilbert recommends focusing on nutrient density and protein intake above all else