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In research subjects, this results in measurable changes in feeding patterns, caloric intake, and appetite-related behaviors

If you plan to discontinue tirzepatide, consider a gradual dose reduction over 8-12 weeks

Nonetheless, insulin/IGF signaling has been demonstrated to attenuate inflammatory responses, e.g., in human myocardial infarction [21] and severe thermal trauma [22] as well as in many mouse models, such as colitis [23], vascular inflammation [24], IL-1-induced cartilage degradation [25], lipopolysaccharide-provoked brain injuries [26], and experimental multiple sclerosis and autoimmune diabetes [27, 28]

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