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The most commonly reported adverse effects in Phase 2 trials were gastrointestinal in nature, including: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and most pronounced during dose escalation, typically improving over time
The Why: This is the bodys most direct signal for hydration
The side effects are primarily those associated with tirzepatide itself: nausea, constipation, diarrhea, decreased appetite, and injection site reactions
Any nausea from the dose peaks while you're asleep
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