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If you regularly take cortisone, hydrocortisone, prednisone, or a similar drug, you may be at higher risk for hypercortisolism (high cortisol levels).18 The risk applies to topical corticosteroid use, too.85 86 ACTH-producing tumors Recall that ACTH secretion by the pituitary gland leads to cortisol production by the adrenals

At the same time, research from the National Institutes of Health found people taking semaglutide (the active ingredient in Ozempic and Wegovy) actually showed lower rates of reported suicidal thoughts compared with those on other weight-management drugs

However, there is no strong evidence that injections are safer or produce permanent results