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Summary: Vitamin B12 supplementation in elderly patients is generally safe and well-tolerated, with most side effects being mild and transient, such as injection site reactions or minor gastrointestinal symptoms

Summary: GLP-1 medications do not directly affect periods, but the significant weight loss they cause can indirectly influence menstrual regularity through hormonal and metabolic changes

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However, the cell death, proteasome inhibition and apoptosis were observed using 1 mM ibuprofen, which is significantly higher than the peak ibuprofen concentrations found in human blood (58.4 g/mL or 283.09 M) after high doses of ibuprofen 39 , and as such may not be physiologically relevant