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The most common side effects (nausea, fatigue, mild headache) tend to peak 12-36 hours after each dose, especially during the first few months and at dose increases
NICE guideline NG28 supports the use of GLP-1 receptor agonists as add-on therapy to metformin when specific criteria are met, including inadequate glucose control despite optimised treatment
Compounded versions are legal when prescribed by a licensed healthcare provider and prepared by a licensed compounding pharmacy
Despite this short plasma half-life, the downstream GH pulse it triggers lasts 2-3 hours, and the resulting IGF-1 elevation persists for 12-18 hours
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