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In the United States, the FDA has also not yet approved retatrutide, though Eli Lilly has announced that it received Fast Track designation from the FDA for the treatment of obesity a status that facilitates more frequent communication between the developer and the regulator to help expedite the review process

"Combination Therapies for Obesity: Cagrilintide and GLP-1 Receptor Agonist Synergy." Nature Reviews Endocrinology, 18(9), 541-556

Natural GLP-1 is easily degraded by enzymes with a short half-life of only 2-5 minutes, making it unavailable for direct therapeutic use

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