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These findings underscore the necessity of carefully selecting and reporting EV-inhibiting pharmacologic agents, as each compound uniquely shapes both the quantity and biological cargo of released EVs, and may have physiological consequences

Both play an essential role not only in the production of melatonin, but also in the circadian control of its release during the day and night

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S -nitrosocysteine can enter the cells via the L-type amino-acid transporter (Hogg et al., 1997) and be reduced to release NO or transfer NO to proteins and thus mediate NO signaling