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A 2014 study discussed evidence of NAC helping to reduce COPD exacerbations and improving small airways function
Data Animal Data In embryo-fetal development studies, sitagliptin administered to pregnant rats and rabbits during organogenesis (gestation day 6 to 20) did not adversely affect developmental outcomes at oral doses up to 250 mg/kg (30-times the 100 mg clinical dose) and 125 mg/kg (20-times the 100 mg clinical dose), respectively, based on AUC
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Compared to the first generation of GLP-1RAs (e.g., exenatide), newer GLP-1RAs (e.g., semaglutide) and poly agonists (e.g., tirzepatide, retatrutide) have higher affinity for the GLP-1R, longer half-lives, and are more potent, leading to high efficacy for glucose control and weight reduction [201,202,203]
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