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Glutathione's role in mitochondrial protection means that cellular energy production becomes more efficient as oxidative burden declines
Itaconate, derived from citrate produced in the TCA cycle, contains ,-unsaturated carboxylic acid, and covalently modifies at the Cys151 residue of Keap1 (78)
Following MTX injection (in physiological saline, 20 mg/kg, single dose), either saline (MTX group, n 8) or WPC (2 g/kg, oral gavage, MTX + WPC group
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