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Paradoxically, PFKFB3 expression is reported to correlate with pro-invasive and pro-inflammatory activity in rheumatoid arthritis patients (218, 219), while selective inhibition of endothelial PFKFB3 reduces polarization of M2 macrophages (189)
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These advances underscore the potential of gene-based interventions to transform the management of HF, offering hope for durable improvements in cardiac function
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![Glucagon-like peptide-1 (GLP-1) receptor agonists (semaglutide [Wegovy, Ozempic, Rybelsus]) & dual incretin agonists (tirzepatide [Zepbound, Mounjaro]) are medications that reduce food cravings, increase fullness, slow digestion, & can help control](https://lookaside.fbsbx.com/lookaside/crawler/threads/DMNbTJuxCjp/0/image.jpg)
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