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According to FDA prescribing information, gastrointestinal side effects vary by dose and indication, with nausea occurring in up to approximately 33% of patients taking Zepbound (with somewhat lower rates for Mounjaro)
Naiki-Ito A, Asamoto M, Hokaiwado N, Takahashi S, Yamashita H, Tsuda H, Ogawa K, Shirai T
Thus, the different volume regulation by SGLT2-I may limit the aberrant neurohumoral and RAAS stimulation that occurs in the setting of volume depletion (54, 55)
Conclusion The evolution from semaglutide to tirzepatide to triple agonists represents a fascinating progression in metabolic research
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