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While their mechanisms of action are similar, topical acetyl hexapeptide-8 does demonstrate a lower efficacy than injected Botox, but as researchers note this is to be expected.22 Similar results were found in a small 2013 study, with the total anti-wrinkle efficacy of the Argireline treatment group being 48.9% compared to 0% in the placebo group.23 However, a more recent 2023 study investigating the effects of serum containing Argireline and hyaluronic acid found the results to be not statistically significant.24 This means that more research is needed before claims that Argireline is a true alternative to Botox can be confirmed or denied
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Energy and mood benefits may gradually decrease over time, which is why ongoing maintenance injections are often recommended
The same polymorphism was subsequently demonstrated to have a significantly lower incidence in patients who developed hepatotoxicity from unintentional paracetamol overdose when compared to liver failure from other causes [32]
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