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Seek urgent medical attention (call 999 or go to A&E) if you experience: Severe allergic reaction (anaphylaxis) with symptoms such as difficulty breathing, swelling of the face, lips, or throat, or severe skin rash Signs of pancreatitis: severe, persistent abdominal pain that may radiate to the back, often accompanied by nausea and vomiting Severe confusion, extreme drowsiness, or difficulty staying awake Thoughts of self-harm or suicide Call NHS 111 or contact your GP urgently if you experience: Persistent or severe nausea and vomiting that prevents you from taking medications or staying hydrated Unusual dizziness, falls, or impaired coordination Signs of gallbladder problems: yellowing of skin or eyes, severe upper abdominal pain, fever Worsening anxiety or panic attacks despite treatment Any new or worsening side effects from either medication Difficulty reducing or stopping Xanax, or withdrawal symptoms such as increased anxiety, tremor, or sleep disturbance If you have diabetes and are taking insulin or sulfonylureas: symptoms of hypoglycaemia (low blood sugar) Routine reviews are essential when taking these medications

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