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In addition to its HSA-mediated pharmacokinetic extension, albiglutide exhibits enhanced stability against enzymatic degradation by DPP-4

This is largely because peptides are too big to be properly absorbed through the intestine walls after oral ingestion

In addition to hormone release, signals from the microbiome influence GBA via vagal afferent pathways that connect to the brainstem and hypothalamic areas responsible for feeding behavior, reward processing, and metabolic controlneural circuits that largely overlap with networks responsive to GLP-1 [121,122]

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