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The GSH transport between the various cell compartments is vital to buffer reactive oxygen species (ROS) and facilitate redox signaling in order to control cell growth, development and defense, as well as regulate cell proliferation
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In contrast to GSH synthesis, which occurs intracellularly, GSH degradation occurs exclusively in the extracellular space, and in particular, on the surface of cells that express the enzyme -glutamyl transpeptidase (also called -glutamyl transferase, GGT
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