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If the problem is desire rather than mechanics, brain-acting peptides are the appropriate tool

The method's modular nature and lack of dependence on a training set make it attractive for exploring relative binding trends and guiding computational screening, yet it relies on several approximations, including incomplete treatment of conformational entropy and neglect of contributions from ordered binding-site water molecules [47, 48]

doi: 10.1016/j.bmc.2018.09.004 213 KupliskaA.RzdK